Gene Study Adds to investigate of Breast Cancer Risk

Findings may help scientists develop way to predict creature risk in BRCA1 mutation carriers. Newly recognized gene mutations may affect breast cancer risk in some women, an international team of researchers has found.
It is already known that BRCA1 gene mutations significantly increase the risk of breast and ovarian cancer. This new study looked at whether other gene mutations might adjust or alter that breast cancer risk.
The Mayo Clinic-led team first studied genetic mutations in 1,193 women with BRCA1 mutations who had enveloping breast cancer and 1,190 women with BRCA1 mutations who didn't have breast cancer. They then used those results to study a larger sample of women in each group.
The investigators finally identified five gene mutations in the region of chromosome 19p13 that modify breast cancer risk in women with BRCA1 gene mutations. But these mutations do not distress ovarian cancer risk in these women, the researchers noted.
The findings, available in the current issue of the journal Nature Genetics, may help improve understanding of the causes of breast cancer and "should be useful in helping determine individual risk for breast cancer in BRCA1 carriers," senior author Fergus Couch said in a news release from the Mayo Clinic.

Know more about Cancer

8 cancer symbols highlighted

There are eight signs, symptoms or test consequences that could improve early diagnosis of some cancers, British doctors said,
The researchers focused on changes that gave a one in 20 or higher chance of rotating out to be cancer.
The symptoms contain:

• Coughing up blood.

• Rectal blood.

• Breast lump or mass.

• Difficulty swallowing.

• Post-menopausal bleeding.

• Abnormal prostate tests.

• Anemia.

• Blood in urine.

In certain age and sex groups, the eight symptoms or findings point to the require for urgent examination by family doctors, Dr. Mark Shapley and colleagues from Keele University (halfway between Manchester and Birmingham) said in Friday's online issue of the British Journal of General Practice.
The conclusion was based on an study of 25 studies from the U.K., U.S., Netherlands, Belgium, Australia, Denmark and Germany.
The age of the patient is significant, said Dr. Kevin Barraclough, a GP from Stroud.
"Iron deficiency anemia in a 21-year old female is really unlikely to be due to colorectal cancer, whereas in a 60-year old male, cancer is likely," Barraclough wrote in a journal editorial accompanying the study.
The red flags support the importance of encouraging patients to discuss worrying symptoms early with their GP, said Prof. Amanda Howe, honorary secretary of the Royal College of General Practitioners, which publishes the magazine.